Development and Validation of a Liquid Chromatographic/ Mass Spectrometric Method for the Determination of Saikosaponin a in Rat Plasma and its Application to Pharmacokinetic Study
نویسندگان
چکیده
Chaihu (Radix bupleuri, Chinese thorowax root) is a favorite medicinal herb in traditional Chinese medicine (TCM) and is used as a key ingredient herb for many Chinese multiherb remedies. There are 40 species of the Bupleurum grown wide in china, while only two of them, the dried roots of Bupleurum Chinese DC., known in commerce as ‘Bei chaihu’ (Northern Chinese Thorowax Root) and the dried roots of Bupleurum scorzonerifolium Wild., known as ‘Nan chaihu’ (Southern Chinese Thorowax Root), are used in therapeutic practice. In China, Radix bupleuri is traditionally used to relieve fever, to calm the liver and to cure drooping and ptosis [1].
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